Insulin Receptor Substrate Proteins

A structurally-related group of signaling proteins that are phosphorylated by the INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation, insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins that are involved in insulin receptor signaling.

Also Known As:

IRS Signaling Adaptor Proteins; Insulin Receptor Substrate-1; Insulin Receptor Substrate-1 Protein; Insulin Receptor Substrate-2; Insulin Receptor Substrate-2 Protein; Insulin Receptor Substrate-3; Insulin Receptor Substrate-3 Protein; Insulin Receptor Substrate-4; Insulin Receptor Substrate-4 Protein; Insulin Receptor Substrate 1; Insulin Receptor Substrate 1 Protein; Insulin Receptor Substrate 2; Insulin Receptor Substrate 2 Protein; Insulin Receptor Substrate 3; Insulin Receptor Substrate 3 Protein; Insulin Receptor Substrate 4; Insulin Receptor Substrate 4 Protein

Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Carrier Proteins: 13306
    - Signal Transducing Adaptor Proteins
      - Insulin Receptor Substrate Proteins: 1034
  - Intracellular Signaling Peptides and Proteins: 32
    - Signal Transducing Adaptor Proteins
      - Insulin Receptor Substrate Proteins: 1034
- Peptides: 84029
  - Intracellular Signaling Peptides and Proteins: 32
    - Signal Transducing Adaptor Proteins
      - Insulin Receptor Substrate Proteins: 1034

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Disease

Drug/Important Bio-Agent (IBA)